In preparing the second edition of this well known work (the first appeared in 1928), the author has added some 6,000 references to the bibliography. The format is excellent and the bibliography extensive (but not complete) and well arranged; the book may therefore be useful for reference. However, there are a great many serious omissions from the text (for instance, the fundamental work of Hanson on the parathyroid is not even mentioned) and many of the discussions are uncritical and inaccurate. Much of the work is simply a compilation from the literature. Thus this volume, like so many others on the difficult subject of endocrinology, has a decidedly limited usefulness.