Sprue long has been one of the puzzles of medicine. Whereas some have thought that infection takes place from patient to patient, others have offered1 as contributing causes tropical residence, high altitude, digestive disturbances, food deficiency, calcium deficiency, streptococci and Monilia. In this country and in the West Indies, Monilia has received serious attention, largely through the influence of Ashford. He has modified his original ideas, however, and now believes that Monilia psilosis is an infection of the gastro-intestinal tract superimposed on glandular insufficiency. Wood2 has recently found Monilia psilosis constantly present in the stools of persons with pernicious anemia.
The similarity between pernicious anemia and sprue has impressed a number of investigators. It is not surprising, therefore, that the treatment by means of liver and liver extract, which has proved of such great benefit in pernicious anemia, should also have been tried in the treatment of sprue.