JAMA. 1943;121(10):715-720. doi:10.1001/jama.1943.02840100001001.
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The main clinical characteristics of portal cirrhosis are well known. It is most frequently seen during the fifth and sixth decades, the average age being close to 50 years (table 1). Men are more frequently affected than women, the proportion being approximately three to one. The results of a study of 108 cases seen at the New York Post-Graduate Hospital (table 2) were very similar to those reported recently from New York by Patek and Ratnoff,1 by Fleming and Snell2 at the Mayo Clinic and by Wayburn and Guerard3 from San Francisco. These studies in turn do not differ greatly from the earlier reports of Wickham Legg,4 Murchison5 and Rolleston.6

Clinical studies regarding the pathogenesis of this condition are equivocal. The history of the abuse of alcohol is a frequent but not essential finding. Syphilis was present in about one sixth of the cases


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