This report is concerned with some observations on the effect of epinephrine made in our laboratory in conjunction with A. H. Wightman and J. W. Huffman. These studies were prompted by a number of reports in the literature indicating that the modifying effects of anesthesia on the vascular response to epinephrine were exceedingly significant. These modifications have not been always sufficiently considered in interpreting various experimental results in terms of the physiologic significance of the suprarenal glands.
A few of these reports may be cited. Hartman and Fraser1 in 1917 noted that, while recording the blood pressure of a dog after exposure of the femoral artery by means of local anesthesia, injections of epinephrine in doses which in other animals gave a fall in blood pressure caused either no effect or only a rise. They concluded, however, that the local anesthetic inhibited the action of the epinephrine vasodilator mechanism.