JAMA. 1928;91(14):1020-1024. doi:10.1001/jama.1928.02700140022006.
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In connection with the therapeutic use of malaria for the treatment of paresis in this clinic, we were interested in trying out the same treatment in cases of tabes and cerebral syphilis, especially choosing patients who previously had not responded to the use of the usual intensive antisyphilitic methods. My purpose in this study was to see whether malaria could be added to the armamentarium directed toward the treatment of tabes and cerebral syphilis and whether a course of therapeutic malaria would result in any symptomatic improvement, especially in cases in which there were lightning pains which did not respond to other types of treatment. I was also interested in using malaria for a small group of previously untreated cases of tabes and cerebral syphilis to determine whether the course of the disease was unfavorably or favorably influenced. With these objects in mind the present studies were begun in August,


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