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JAMA. 1928;91(14):1008-1012. doi:10.1001/jama.1928.02700140010003.
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The ovary with its multiple functions has a tremendous possibility for pathologic changes. The function of importance in connection with papilliferous cyst carcinoma is the activity of its germinal epithelium and its tendency to proliferation. Proliferating epithelium, as is well known, is the basis of a certain kind of neoplastic formation, such as papilliferous cystic tumors. These papilliferous cysts may be benign adenomas or malignant carcinomas. In a number of cases the benign growth is the forerunner of the malignant tumor. Both types of cysts have a marked tendency to be bilateral and to develop psammoma bodies; they may be single or multilocular and both may contain bloodtinged fluid and more or less gelatinous material, as well as ascites, which, however, is more common in the malignant growth. The importance of distinguishing between the two types is obvious.

Macroscopically, papilliferous cyst adenoma in situ appears as a multilocular cyst with


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