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ESTROGENIC HORMONES AND CARCINOGENESIS

LEO LOEB, M.D.
JAMA. 1935;104(18):1597-1601. doi:10.1001/jama.1935.92760180004009.
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Note.  —This article and the articles in the previous issues of The Journal are part of a series published under the auspices of the Council on Pharmacy and Chemistry. Other articles will appear in succeeding issues. When completed, the series will be. published in book form.—Ed.Three lines of investigation, conducted more or less independently of one another for a number of years, have led recently to the conclusion that a remarkably close relation in chemical constitution as well as in biologic effects exists between estrogenic hormones and certain hydrocarbons that occur in tar and are able to induce cancer. The facts that resulted directly in the formulation of this problem came in part from investigations of Kennaway, Cook and Dodds and their collaborators concerning the chemical constitution of the carcinogenic constituents of tar and the ability of these and related substances to induce estrus and in part from another

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