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TREATMENT OF NEUROSYPHILIS BY MALARIA:  SEROLOGIC RESULTS AND A COMPARISON WITH TREATMENT BY TYPHOID VACCINE

PAUL A. O'LEARY, M.D.
JAMA. 1928;91(8):543-545. doi:10.1001/jama.1928.02700080015006.
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In previous reports, I1 have called attention to the status of a group of 100 cases of neurosyphilis in which the treatment by malaria had been given between June, 1924, and February, 1926. In fifty-seven of these cases paresis was present, and in forty-three there were other manifestations of resistant neurosyphilis. It is my purpose in this report to emphasize the results of treatment by malaria in 138 cases of the nonparetic type, with particular reference to the serologic studies, and to compare briefly this method with that of treatment by typhoid vaccine. The status of the cases of asymptomatic neurosyphilis in which treatment by malaria was given will also be emphasized.

In the group of "asymptomatic neurosyphilis" are included the cases in which the spinal fluid remained positive following the intensive use of arsphenamine, mercury, bismuth, the iodides and intraspinal medication, and in which clinical signs and symptoms

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