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A TENTATIVE CLASSIFICATION OF ALLERGIC DERMATOSES

MARION B. SULZBERGER, M.D.; FRED WISE, M.D.; JACK WOLF, M.D.
JAMA. 1935;104(17):1489-1490. doi:10.1001/jama.1935.02760170027008.
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The accompanying illustration and table give our suggestion for a schematic and tentative classification of the various common allergic dermatoses. The division is based on (a) the site of the shock tissue (epidermis or cutis) and (b) the length of time required for the development of the visible reaction, after the union of allergen and sensitized tissue.

In each of the first three groups the reaction to skin testing is characteristic: this has served as the criterion

Classification of Various Common Allergic Dermatoses

  • Eczematous Reactions

    1. Site of shock tissue: epidermis

    2. Reaction time: twenty-four or more hours

    3. Characteristic lesion: spongiosis and intra-epidermal vesicle

    4. Causative substances: frequently simple chemicals or products of fungi

    5. Type of test: patch test

  • Tuberculin-Trichophytin-Type Reactions (not infrequently combined with eczematous responses)

    1. Shock tissue: upper cutis, cutis

    2. Reaction time: from twenty-four to forty-eight or more hours

    3. Characteristic lesion:

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