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PROTECTIVE ACTION OF CONVALESCENT POLIOMYELITIS SERUM

SIMON FLEXNER, M.D.; FRED W. STEWART, M.D.
JAMA. 1928;91(6):383-384. doi:10.1001/jama.1928.02700060017006.
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The employment of convalescent serum in the early treatment of human cases of poliomyelitis is based on decisive experiments in monkeys. These experiments are divisible into two classes, in one of which proof was brought that the virus of poliomyelitis and convalescent serum mixed in vitro does not produce experimental poliomyelitis, and in the other of which it was shown that under controlled experimental conditions the intrameningeal injection of the convalescent serum, even as late as from eighteen to twenty-four hours after an intracerebral injection of the virus, sufficed to prevent an otherwise certain development of the paralytic experimental disease. In the carrying out of these tests, it is immaterial whether convalescent human or convalescent monkey serum is employed, but normal serum of either source is without effect. Moreover, as the intrameningeal injection of the convalescent serum is effective against an intracerebral inoculation of the virus, it is to be

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