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SULFATHIAZOLE IN EPIDEMIC SONNE DYSENTERY

HERMAN YANNET, M.D.; ALBERT LEIBOVITZ, M.S.; JOYCE V. DEUTSCH, M.D.
JAMA. 1942;120(3):184-188. doi:10.1001/jama.1942.02830380016005.
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The beneficial effects of sulfathiazole and sulfaguanidine on the clinical course of endemic bacillary dysentery has been clearly demonstrated.1 The febrile period and the length of time during which abnormal stools occur are definitely shortened. Insufficient data, however, are available to evaluate the effects of the sulfonamide drugs on the two factors which have important epidemiologic implications, namely the length of time elapsing before the dysentery bacillus can no longer be demonstrated in the stools and the incidence of relapses. The importance of these two factors in the control of epidemics occurring in institutions, schools, camps and the like has been frequently stressed. Our purpose in the present communication is to describe the study of a relatively small outbreak of Sonne dysentery in which data were obtained bearing on these two points.

METHODS  Material for cultural study was obtained by the insertion of a finger, protected by a finger

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