At the age of 75 the author reviews his life and work from the beginning in a small Canadian community to emeritus professor in Johns Hopkins University and retired physician in Baltimore. After his medical course at the University of Toronto he worked with Osier, Welch and Mall at Hopkins until 1900, when he went to the University of Chicago, returning in 1905 to Hopkins as Osler's successor as head of the department of medicine. In the meantime he made important contributions to the study of anatomy and served as member of a medical commission to the Philippines in 1899, when he also visited plague stricken districts in India and China. In 1901 he served on a federal commission on plague in San Francisco.
With Franklin P. Mall, the anatomist, Barker advocated full time appointments in clinical branches, which went into effect in the Hospital of the Rockefeller Institute for