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ARTICLE | December 15, 1934

A Contribution to the Problem of the Relationship Between the B Vitamins and the Protein, Fat and Carbohydrate Contents of Food

JAMA. 1934;103(24):1881. doi:10.1001/jama.1934.02750500063035.

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ABSTRACT

This report, in Danish, accompanied by an English summary, covers experimental investigations (1929-1931) in which mice were used to ascertain whether requirements for the B vitamins vary at different levels of protein, fat and carbohydrate in the diet. This question is important in the quantitative determination of the B vitamins as well as from a clinical standpoint. When given a rich fat diet, the animals seemed to need less vitamin B₁, while the requirement of B₂ seemed to be increased; increased vitamin B₁ caused an earlier development of pellagra and death. A high carbohydrate diet seemed to increase the need for B₁ and/or B₄. A high protein diet appeared to increase B₂ needs. The results of the experiments show that the composition of the diets on which experimental animals are fed has a large influence on the quantitative biologic determinations of the constituents of

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A Contribution to the Problem of the Relationship Between the B Vitamins and the Protein, Fat and Carbohydrate Contents of Food. JAMA. 1934;103(24):1881. doi:10.1001/jama.1934.02750500063035.

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