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JAMA. 1931;96(19):1638-1639. doi:10.1001/jama.1931.02720450080021.
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ABSTRACT

Lectures on Histoneurology  Dr. Pio del Rio-Hortega, a pupil of Ramon Cajal, who has devoted himself to the study of the histology of the central nervous system, was recently invited to address the medical societies of Munich, Berlin, Hamburg, Friburg and Heidelberg in Germany. The topic of his first lecture was "Microglia in Rest and in Physiopathologic Activity." Microglia cells were described by him in 1919 as a special type of nonneural cells of the nervous centers. These cells are provided with protoplasmic prolongations, and during the pathologic processes of the central nervous system they migrate in large numbers to the site of the lesion to act as phagocytes on the waste products at the same time that they give origin to the so-called rod-shaped cells and granulo-adipose cells. Microglia cells are the only ones that carry out the phagocytic processes in the nervous centers. Microglia cells in the nervous

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