JAMA. 1934;103(22):1671-1678. doi:10.1001/jama.1934.02750480009003.
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It is 130 years since hemophilia was first observed and accurately described by Otto.1 The progress in its therapy has been slow and full of disappointments. This report will deal with a review of the methods of treatment of the condition at the disposal of the physician today. It is based partially on observations made on twelve hemophilic patients at various times over a period of seven years.

For the purpose of this discussion, hemophilia is defined as an inherited or noninherited tendency of males to bleed, characterized by the presence of a prolongation of the coagulation and prothrombin time of the venous blood. Cases of hemophilia in which a history of inheritance is not obtainable are included. Five of our patients fall in this group, although four of them have brothers similarly affected. Instances of so-called sporadic hemophilia are about as frequent as those in which a clear-cut


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