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ARTICLE |

PRESERVATION OF LIQUID PLASMA BY SULFONAMIDE DERIVATIVES

Milan Novak, M.D.
JAMA. 1942;119(1):101. doi:10.1001/jama.1942.02830180103024.
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ABSTRACT

To the Editor:—  In the February 14 issue of The Journal I published a paper on the preservation of liquid plasma by the use of sulfonamide derivatives. The report was based on hundreds of experiments employing numerous species of bacteria encountered as contaminants in stored plasma. In no instance did I demonstrate growth of bacteria in plasma containing 200 mg. per hundred cubic centimeters (0.2 per cent) of sodium sulfathiazole, nor did plasma containing the compound become grossly contaminated when exposed to air contamination for long periods of time.In The Journal of March 28, Heath and Province published their results on a small series of experiments carried out under unusual conditions in that they do not represent actual working conditions and made broad conclusions which do not discredit my own but tend to cast doubt on the efficacy of the sulfonamide method. In their experiments they used only five

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