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Sodium Excretion, Cardiovascular Disease, and Chronic Kidney Disease

Mehmet Hursitoglu, MD1
[+] Author Affiliations
1Department of Internal Medicine, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey
JAMA. 2016;316(10):1112. doi:10.1001/jama.2016.11550.
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To the Editor In the study by Mills and colleagues,1 high urinary sodium excretion was associated with increased cardiovascular disease (CVD) risk in patients with chronic kidney disease (CKD). Patients were divided into 4 groups based on quartiles of calibrated urinary sodium excretion (<2894 mg/24 hours; 2894-3649 mg/24 hours; 3650-4547 mg/24 hours; and ≥4548 mg/24 hours) and were followed up for a median of 6.8 years. The cumulative incidence of CVD for each group from lowest to highest urinary sodium excretion was 18.4%, 16.5%, 20.6%, and 29.8%, respectively. After multivariable adjustment, no significant association was found between urinary potassium excretion and CVD events.


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September 13, 2016
Jaume Almirall, MD
1Department of Nephrology, Parc Tauli Sabadell, Hospital Universitari, Barcelona, Spain
JAMA. 2016;316(10):1112. doi:10.1001/jama.2016.11553.
September 13, 2016
Katherine Mills, PhD, MSPH; Jiang He, MD, PhD
1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
JAMA. 2016;316(10):1112-1113. doi:10.1001/jama.2016.11558.
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