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Research Letter |

Five-Year Survival After Endosonography vs Mediastinoscopy for Mediastinal Nodal Staging of Lung Cancer

Jolanda C. Kuijvenhoven, MD1; Daniël A. Korevaar, MD2; Kurt G. Tournoy, MD, PhD3; Thomas L. A. Malfait, MD4; Christophe Dooms, MD, PhD5; Robert C. Rintoul, FRCP, PhD6; Jouke T. Annema, MD, PhD1
[+] Author Affiliations
1Department of Respiratory Medicine, Academic Medical Center, Amsterdam, the Netherlands
2Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, Amsterdam, the Netherlands
3Department of Respiratory Medicine, Onze-Lieve-Vrouw Hospital, Aalst, Belgium
4Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium
5Department of Respiratory Medicine, Leuven University Hospitals, Leuven, Belgium
6Papworth Clinical Trials Unit Collaboration, Papworth Hospital, Cambridge, United Kingdom
JAMA. 2016;316(10):1110-1112. doi:10.1001/jama.2016.10349.
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This study reports 5-year survival data for participants in a 2010 trial comparing the diagnostic accuracy of endosonography vs mediastinoscopy for lung cancer staging.

Lung cancer accounts for the highest cancer-related mortality rate worldwide.1 Accurate mediastinal nodal staging is crucial in the management of non–small cell lung cancer (NSCLC) because it directs therapy and has prognostic value.2,3

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Survival Among Patients With Lung Cancer in the Endosonographic vs Surgical Staging Strategies

Adjusted for mediastinal nodal metastases status (N0/N1 vs N2/N3) (adjusted hazard ratio, 0.98 [95% CI, 0.73-1.32]). The median duration of follow-up was 33 months (interquartile range [IQR], 13-76) for surgical staging and 31 months (IQR, 13-75) for endosonographic staging.

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