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JAMA Clinical Evidence Synopsis |

Colchicine and Prevention of Cardiovascular Events

Lars G. Hemkens, MD, MPH1; Hannah Ewald, MPH1; Matthias Briel, MD, MSc1,2,3
[+] Author Affiliations
1Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
2Department of Clinical Research, University of Basel, Basel, Switzerland
3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
JAMA. 2016;316(10):1106-1107. doi:10.1001/jama.2016.11044.
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Clinical Question  Is continuous long-term treatment with colchicine associated with lower rates of all-cause mortality and myocardial infarction and higher rates of adverse events?

Bottom Line  Continuous long-term treatment with colchicine may be associated with lower rates of myocardial infarction, but may be associated with higher rates of gastrointestinal adverse events.

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