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JAMA. 1942;118(17):1452-1454. doi:10.1001/jama.1942.02830170030011.
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An editorial in the May 4, 1935 issue of The Journal pointed out some of the inadequacies of the circulatory, the infectious and the mechanical functional theories of the genesis of gastroduodenal ulceration; it concluded that "the accumulated clinical and experimental observations force the clinician and the experimental worker once more to look to the digestive part of the gastric secretion as the most important factor in the genesis of the ulcer." A symposium by physiologists, internists and surgeons in a recent issue of the Archives of Surgery reemphasizes the importance of the acid gastric secretion in the causation of gastroduodenal ulcer. Schiffrin and Ivy1 state that destruction of gastric tissue results from the proteolytic action of the gastric juices. They do not wish to imply that the excessive secretion of gastric juice or its retention in the stomach is the cause of gastroduodenal ulcer. They believe, however, that


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