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THE USE OF SULFADIAZINE AND SULFATHIAZOLE IN DIABETES MELLITUS

CHARLES W. STYRON, M.D.; HARRY BROMLEY, M.D.; HOWARD F. ROOT, M.D.
JAMA. 1942;118(17):1423-1427. doi:10.1001/jama.1942.02830170001001.
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Treatment of 100 consecutive diabetic patients by means of sulfathiazole and sulfadiazine is here reported with respect to the toxicity of these drugs in diabetes mellitus, their effect on the control of diabetes and the efficiency of the treatment in various types of infection.

Sulfanilamide became generally available in 1937. It was found to be effective against beta hemolytic streptococci, meningococci, urinary tract infections, trachoma, chancroid and lymphogranuloma venereum. To a less extent it was effective in gonorrheal infections, undulant fever and actinomycosis. In 1939 sulfapyridine was widely and effectively used in pneumococcic infections and gonorrheal infections. In 1940 sulfathiazole proved more effective and less toxic in staphylococcic infections, and in 1941 sulfadiazine was introduced as even more efficient against all organisms than the drugs mentioned and, in addition, it was found active in Friedländer infections.

Recently Beardwood and Rouse1 attributed three cases of diabetic acidosis to the administration

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