The Hortense Schoen Joseph Premature Station of Michael Reese Hospital has a record for saving the lives of premature infants somewhat better than that of most institutions concerned with this field. The record has been accomplished by the introduction of complete control of the environment, the maintenance of aseptic nursing care and the introduction of special technics for bathing, dressing, feeding and otherwise providing for the infant. In this book the physician who has had charge of this work and the nurse who has been responsible for the meticulous detail have cooperated. Indeed, the work itself is so impressive that it has now been related to the entire program for the care of the premature infant in Chicago. It represents a challenge to all others concerned with similar work.