With Zika infection, as with other emerging infections, astute clinicians have been critical to recognition of new patterns of disease. Keeping up with rapidly changing guidance amid multiple clinical demands is difficult. Obstetricians and gynecologists should ensure access to contraception on request and provide sensitive care and counseling for women with laboratory evidence of Zika infection. The Centers for Disease Control and Prevention (CDC) updates travel alerts and interim guidance for clinicians, including recently updated guidance on diagnostic testing.5 Clinicians need to know how and for whom to test for Zika infection and how to interpret results. Laboratory algorithms have evolved as new information emerges, including the utility of testing urine specimens up to 2 weeks after symptoms appear. Further and frequent enhancements to laboratory testing guidelines are likely as the CDC and others conduct rapid-cycle research to optimize detection of Zika infection. To detect local transmission of Zika, clinicians in areas at risk need to test patients without travel to Zika-affected areas, such as patients with fever, rash, joint pain, or conjunctivitis. The CDC is working with the American Academy of Pediatrics to provide interim guidance for evaluation, monitoring, and treatment of infants born following Zika-affected pregnancies.