JAMA. 1934;103(15):1129-1135. doi:10.1001/jama.1934.02750410019004.
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As we arrive in this world an intricate physiologic interruption in the circulation takes place which separates us from the maternal blood stream and places us entirely on our own. The success of this remarkable and most interesting process in the beginning of a new life hinges on a normal physiologic reaction; namely, thrombosis and the rapid healing or closing of an injured blood channel. As we depart from this biologic battle the last physiologic change in our bodies after our heart has ceased to beat is the clotting of blood within our veins.

During the interval between these terminal events of life, most of the pathologic changes that take place in the body have either directly or indirectly some bearing on the problem of thrombosis and the subsequent repair of this vascular damage. The healing of all wounds, the constant battle with infections, as well as the development and


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