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Comment & Response |

Definitions for Sepsis and Septic Shock

Verena Schneider-Lindner, MD, PhD1; Holger A. Lindner, PhD1; Manfred Thiel, MD1
[+] Author Affiliations
1Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
JAMA. 2016;316(4):457. doi:10.1001/jama.2016.6380.
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To the Editor The new consensus definition for sepsis (Sepsis-3)1 relies on interpretation of a study on the performance of several scores in patients with suspected infection for mortality prediction.2 Although this is a commendable step forward compared with previous expert opinion-based criteria definitions,3 we fear unintended adverse effects. Unsurprisingly, as the SOFA score was developed for predicting mortality, it outperformed SIRS in the hospital setting.2 Based on this result, the authors abandoned SIRS from the sepsis definition, eliminated the first stage of the former sepsis-continuum4 (previously called sepsis), and reclassified it as infection.1

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July 26, 2016
Clifford S. Deutschman, MD, MS; Mervyn Singer, MD, FRCP
1Center for Pediatric Research, Steven and Alexandra Cohen Children's Medical Center, New Hyde Park, New York
2Bloomsburg Institute of Intensive Care Medicine, University College London, London, United Kingdom
JAMA. 2016;316(4):458-459. doi:10.1001/jama.2016.6389.
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