We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Definitions for Sepsis and Septic Shock

Verena Schneider-Lindner, MD, PhD1; Holger A. Lindner, PhD1; Manfred Thiel, MD1
[+] Author Affiliations
1Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
JAMA. 2016;316(4):457. doi:10.1001/jama.2016.6380.
Text Size: A A A
Published online


To the Editor The new consensus definition for sepsis (Sepsis-3)1 relies on interpretation of a study on the performance of several scores in patients with suspected infection for mortality prediction.2 Although this is a commendable step forward compared with previous expert opinion-based criteria definitions,3 we fear unintended adverse effects. Unsurprisingly, as the SOFA score was developed for predicting mortality, it outperformed SIRS in the hospital setting.2 Based on this result, the authors abandoned SIRS from the sepsis definition, eliminated the first stage of the former sepsis-continuum4 (previously called sepsis), and reclassified it as infection.1


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




July 26, 2016
Clifford S. Deutschman, MD, MS; Mervyn Singer, MD, FRCP
1Center for Pediatric Research, Steven and Alexandra Cohen Children's Medical Center, New Hyde Park, New York
2Bloomsburg Institute of Intensive Care Medicine, University College London, London, United Kingdom
JAMA. 2016;316(4):458-459. doi:10.1001/jama.2016.6389.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...