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JAMA. 1928;90(4):249-253. doi:10.1001/jama.1928.02690310001001.
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In 1925, Davidson1 recorded a case of hypothyroidism with nephrosis and tetany. Preliminary treatment with thyroid gland produced some loss of weight and an increase in the volume of urine. Subsequent treatment with parathyroid extract-Collip not only relieved the tetany but caused a rapid subsidence of the edema.

Mason2 observed a patient with chronic nephritis, slight edema and hypocalcemia. Tetany was not observed. Parathyroid extract-Collip was given. Within two days the urine volumes increased and a remarkable readjustment of the altered chemical constituents of the blood occurred, with relief of the symptoms of acute depression in renal function.

Since the report of these cases, it has been possible for me to observe similar results in three edematous patients with nephritis. While these observations were in progress, Meakins3 read a paper before the Association of American Physicians concerning the effects of administration of thyroid and parathyroid preparations to


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