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From The Medical Letter on Drugs and Therapeutics |

Genvoya A New 4-Drug Combination for HIV

JAMA. 2016;316(2):215-216. doi:10.1001/jama.2016.5945.
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This Medical Letter review summarizes a newly approved 4-drug combination comprising elvitegravir, cobicistat, emtricitabine, and tenofovir for treatment of HIV infection in individuals older than 12 years.

The FDA has approved Genvoya (Gilead), a fixed-dose combination of the integrase strand transfer inhibitor (INSTI) elvitegravir, the pharmacokinetic enhancer cobicistat, and the nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) emtricitabine and tenofovir alafenamide, for treatment of HIV-1 infection in patients ≥12 years old. This is the first approval for tenofovir alafenamide (TAF), a tenofovir prodrug. Stribild, a fixed-dose combination of elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate (TDF), was approved in 2012.1

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