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Comment & Response |

Acetazolamide and Invasive Mechanical Ventilation for Patients With COPD

Shakti Mishra, MD1; Afzal Azim, MD1; Arvind Baronia, MD1
[+] Author Affiliations
1Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
JAMA. 2016;316(1):100. doi:10.1001/jama.2016.4622.
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To the Editor The DIABOLO trial examined the effect of acetazolamide vs placebo in patients with COPD.1 We would like the authors to respond to the following points.

First, the literature supporting the role of acetazolamide as a respiratory stimulant is scant and hence acetazolamide is not recommended in most guidelines.2


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July 5, 2016
Christophe Faisy, MD, PhD; Nicholas Heming, MD, PhD; for the DIABOLO Investigators
1Assistance Publique-Hôpitaux de Paris, Paris, France
JAMA. 2016;316(1):100-101. doi:10.1001/jama.2016.4625.
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