0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

THE ARTHUS PHENOMENON: REPORT OF A CASE

Fred E. Ross, M.D.
JAMA. 1934;103(8):563. doi:10.1001/jama.1934.72750340002008b.
Text Size: A A A
Published online

A local necrosis following infrequently repeated subcutaneous injections of horse serum was first noted by Arthus, experimenting with rabbits, in 1903. He described the occurrence of a characteristic set of symptoms which has since been known as the Arthus phenomenon. The symptoms seem to be due to an anaphylactic reaction of antibodies with a specific antigen, which results in the formation of a toxic substance causing local necrosis in the tissues. The reaction is specific for the antigen used.

Since the publication of these and other studies, clinical instances of the Arthus phenomenon have been recorded in the literature with increasing frequency. The results of an exhaustive study of the clinical and serologic aspects of the condition have been reported by Tumpeer and Cope.1 A case exhibiting this phenomenon is here reported.

A boy, aged 4½ years, had been given toxin-antitoxin for diphtheria immunization a year previously. November 22,

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();