0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

THE USE OF SULFACETIMIDE IN BACILLARY INFECTIONS OF THE URINARY TRACT

FERDINAND WELEBIR, M.D.; ROGER W. BARNES, M.D.
JAMA. 1941;117(25):2132-2135. doi:10.1001/jama.1941.02820510020005.
Text Size: A A A
Published online

Recent advances in chemotherapy have been of great benefit in the treatment of infections of the urinary tract. Research in chemotherapeutic agents, especially the sulfonamide compounds, is progressing rapidly. It has been our privilege to have under clinical investigation one of these drugs—sulfacetimide-Schering1 (p-amino- benzene - sulfonyl- acetyl -imide)—which we have used with good results in the treatment of more than 200 cases of infections of the urinary tract due to the colon-aerogenes group of organisms.

In the vast amount of experimental work on sulfanilamide, it was found that it was acetylated in its passage through the body. This acetylation occurs at the amino group in the para position. Vonkennel and Korth2 found that sulfanilamide when acetylated at this particular position became nontoxic but completely lost its therapeutic value.

In an effort to develop a compound which would still be relatively nontoxic yet hold its therapeutic effectiveness in the body, Dohrn and Diedrich3 succeeded in removing one of the hydrogen atoms of the sulfonamide group and placing the acetyl group in this position. The structural formula is:

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();