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Treatment for Patients With Newly Diagnosed Glioblastoma—Reply

Roger Stupp, MD1; Steven A. Toms, MD2; Santosh Kesari, MD, PhD3
[+] Author Affiliations
1Department of Oncology, University Hospital Zurich, Zurich, Switzerland
2Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania
3Department of Translational Neuro-Oncology and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California
JAMA. 2016;315(21):2348-2349. doi:10.1001/jama.2016.1847.
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In Reply Tumor-treating fields are a novel approach to the treatment of cancer. In vitro and animal studies have demonstrated that the use of alternating electrical fields, at a frequency specifically tuned to penetrate tumor cells, interferes with microtubule formation, proper localization of the cytokinetic contractile ring, and chromosomal segregation, leading to cell cycle arrest, apoptosis, and reduced clonogenic potential.13 Little progress has been made in the treatment of glioblastoma over the last decade, yet our study demonstrated a significant improvement in both progression-free and overall survival in patients with glioblastoma.


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June 7, 2016
Marc C. Chamberlain, MD
1University of Washington, Seattle
JAMA. 2016;315(21):2348. doi:10.1001/jama.2016.1844.
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