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JAMA. 1931;96(13):1094. doi:10.1001/jama.1931.02720390104016.
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The Controversy over B C G Vaccine  The veterinarian Lignières continues to pose, before the Academy of Medicine, as an ingrained opponent of the B C G vaccine of Calmette and takes every opportunity to attack it. He does not deny its efficacy and uses it himself on new-born calves to protect them from tuberculosis. But he advises confining its use to the new-born menaced by tuberculous antecedents and living in a tuberculous environment. He contends that the bacilli of the B C G vaccine are susceptible, under certain circumstances, of regaining their virulence; for instance, when they are cultivated in a series on egg yolk. He invokes, furthermore, the observations made in Uruguay by Mr. Hormaeche, which, he alleges, prove that the reappearance of virulence is possible in the guinea-pig if the animal has been previously infected by the streptococcus. Whenever a communication is presented to the academy on


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