0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Risk of Anaphylaxis With Intravenous Iron Products

Cunlin Wang, MD, PhD1; Sarah Wong, MPH2; David J. Graham, MD, MPH1
[+] Author Affiliations
1Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
2ACUMEN LLC, Burlingame, California
JAMA. 2016;315(20):2232-2233. doi:10.1001/jama.2016.0965.
Text Size: A A A
Published online

Extract

In Reply In response to Dr DeLoughery’s concern about diphenhydramine, provided is a sensitivity analysis that excluded all anaphylaxis cases with the claim of “injection of diphenhydramine” (Table 1). Results are consistent with the primary analysis.

Table 1. Risk of Anaphylaxis Without Diphenhydramine at First Administration for New Intravenous Iron Product UsersIntravenous IronIron SucroseFerumoxytolIron DextranIron Gluconate2003-2013No. of anaphylaxis cases269121No. of new users264 166247 50094 400Rate per 100 000 persons (95% CI)9.8 (6.6-14.6)36.8 (29.8-45.4)22.2 (14.1-34.6)Adjusted OR (95% CI)a1 [Reference]3.6 (2.2-6.0)2.2 (1.2-4.2)P valueb<.001.012010 to 2013No. of anaphylaxis cases1217349No. of new users134 83682 11777 93534 029Rate per 100 000 persons (95% CI)8.9 (4.8-16.0)20.7 (12.5-33.9)43.6 (30.7-61.7)26.4 (12.9-52.2)Adjusted OR (95% CI)a1 [Reference]2.4 (1.0-5.7)4.8 (2.2-10.8)2.9 (1.0-8.3)P valueb.06<.001.04

Abbreviation: OR, odds ratio.

aAdjusted for age, indication, coronary heart disease, and hypertension.

bP value adjusted for multiple comparisons.

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

May 24, 2016
Thomas G. DeLoughery, MD, MACP, FAWM
1Division of Hematology/Medical Oncology, Oregon Health Sciences University, Portland
JAMA. 2016;315(20):2232. doi:10.1001/jama.2016.0962.
CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

738 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Jobs
brightcove.createExperiences();