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JAMA. 1934;103(4):264-265. doi:10.1001/jama.1934.02750300038018.
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SCURVY AND CLOTTING OF BLOOD  Although clinical scurvy has become more or less of a rarity in civilized countries, interest in the disease as produced in experimental animals continues. It was in this connection that the first vitamin was synthesized in the laboratory. Again, the success in elucidating the etiology of scurvy and in establishing effective treatment has led to the hope of obtaining further information on the details of the pathogenesis of the disease through experimental studies. Widespread hemorrhage has long been noted as one of the features of the pathology of scurvy, so that attention has been given to changes in the blood itself. Thus concentration of the blood, decrease both in red cells and in hemoglobin, diminution of resistance to hemolysis and decrease in serum proteins have been reported by various investigators. In a recent study Presnall1 has paid special attention to the alterations of the clotting of the blood in


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