JAMA. 1934;103(4):264. doi:10.1001/jama.1934.02750300038017.
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The attention devoted in newspapers and current periodicals to experiments now under way in New York for the development of a vaccine against poliomyelitis recalls the fact that such attempts are not wholly new. As early as 1910, Flexner, Lewis and others attempted to develop an immunizing agent of this type. Abramson in 1917, working in the Laboratories of the Department of Health of the City of New York, tested the value of a vaccine prepared from a virus killed by heat according to a method used by Semple for developing a vaccine against rabies. In his experiments, five monkeys each received successive vaccinations with 5 cc. of a 10 per cent emulsion, each dose of which had been heated to 55 C. for half an hour. Since that time many other investigators have attempted to produce a vaccine that might be established as efficacious, but thus far the results


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