This edition contains new material concerning examination of the plasma, cisterna puncture, pH, albumin quotient, sugar and chloride determinations, and a new paraffin reaction. The handbook, which is condensed and complete, includes a concise practical description of all the tests in use in studies of the blood and spinal fluid in nervous and mental diseases. Description of the normal reactions are given as well as a summary of the results found in many diseases of the nervous system. No explanatory details concerning the theory of the reactions are to be found. In conclusion, the author states that the reactions of the body fluids are to be used only in conjunction with a careful clinical study, and he warns that too great importance should not be given to any single biologic reaction. The book is to be recommended to all laboratory workers.