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SULFATHIAZOLE IN THE TREATMENT OF GONORRHEA IN WOMEN

PAUL F. FLETCHER, M.D.; ORA JAMES GIBSON, M.D.; S. EDWARD SULKIN, Ph.D.
JAMA. 1941;117(21):1769-1773. doi:10.1001/jama.1941.02820470017005.
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The encouraging results obtained by many investigators1 treating gonorrhea in the male with drugs of the sulfonamide series and the relatively few reports2 concerning the use of these drugs in the treatment of gonococcic infection in women suggested the need for further investigation of this problem. Soon after sulfathiazole, the thiazole derivative of sulfanilamide, became available to the medical profession for clinical trial a study was undertaken to determine the efficacy of this drug in a carefully controlled group of hospitalized women. Studies on toxicity in animals by Van Dyke, Greep, Rake and McKee3 and Long, Haviland and their associates4 indicated that the drug could be safely used clinically under carefully controlled conditions. It was found that the sulfathiazole compound was approximately one third less toxic than sulfapyridine, based on 50 per cent end point titrations in mice. Metabolic studies have shown that sulfathiazole is more

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