0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

TP53 Gene and Cancer Resistance in Elephants—Reply

Joshua D. Schiffman, MD1; Dennis L. Schmitt, DVM, PhD2; Carlo C. Maley, PhD3
[+] Author Affiliations
1University of Utah, Salt Lake City
2Ringling Bros Center for Elephant Conservation, Polk City, Florida
3Arizona State University, Tempe
JAMA. 2016;315(16):1790-1791. doi:10.1001/jama.2016.0457.
Text Size: A A A
Published online

Extract

In Reply We agree with Dr Casola that we may have misused the term allele in reference to the additional elephant TP53 (ep53) genes. We also agree, as highlighted in our article, that the exact role of ep53 remains to be determined. Ep53 appears to originate from ancient reverse transcription of TP53 mRNA, followed by a large number of gene duplications. A retrotransposed gene can still encode a protein even if not identical to the ancestral protein, as indicated by our experiments with ep53 retrogene 9. It is unclear if the additional ep53 genes should be called retrogenes or retropseudogenes. Laboratory experiments to answer these questions are ongoing.

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

April 26, 2016
Claudio Casola, PhD
1Department of Ecosystem Science and Management, Texas A & M University, College Station
JAMA. 2016;315(16):1788-1789. doi:10.1001/jama.2016.0440.
April 26, 2016
Raymond P. Perez, MD; Takefumi Komiya, MD, PhD
1Division of Hematology/Oncology, University of Kansas Medical Center, Kansas City
JAMA. 2016;315(16):1789-1790. doi:10.1001/jama.2016.0446.
April 26, 2016
Allan P. Pessier, DVM; Jere K. Stern, BS; Carmel L. Witte, MS
1Institute for Conservation Research, San Diego Zoo Global, San Diego, California
2College of Veterinary Medicine, University of Florida, Gainesville
JAMA. 2016;315(16):1789. doi:10.1001/jama.2016.0449.
CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

456 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Jobs
brightcove.createExperiences();