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Comment & Response |

TP53 Gene and Cancer Resistance in Elephants

Raymond P. Perez, MD1; Takefumi Komiya, MD, PhD1
[+] Author Affiliations
1Division of Hematology/Oncology, University of Kansas Medical Center, Kansas City
JAMA. 2016;315(16):1789-1790. doi:10.1001/jama.2016.0446.
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To the Editor Dr Abegglen and colleagues1 confirmed a low cancer incidence in elephants and hypothesized that this relates to increased genomic protection by p53, possibly due to high copy numbers (20-40) of transcribed p53 pseudogenes. Also, peripheral lymphocytes and fibroblasts in elephants showed greater apoptotic sensitivity to ionizing radiation or doxorubicin than similar cells from humans.


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April 26, 2016
Joshua D. Schiffman, MD; Dennis L. Schmitt, DVM, PhD; Carlo C. Maley, PhD
1University of Utah, Salt Lake City
2Ringling Bros Center for Elephant Conservation, Polk City, Florida
3Arizona State University, Tempe
JAMA. 2016;315(16):1790-1791. doi:10.1001/jama.2016.0457.
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