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THERAPEUTIC VALUE AND EFFECTS OF AMNIOTIN IN GONORRHEAL VAGINITIS IN CHILDREN

JOHN HUBERMAN, M.D.; HOWARD H. ISRAELOFF, M.D.
JAMA. 1934;103(1):18-21. doi:10.1001/jama.1934.02750270020008.
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The serious problem of gonorrheal vaginitis in children has been brought nearer to solution by the ingenious application of a safe and efficient method of treatment, demonstrated by Robert M. Lewis. We are of the opinion that this new radical treatment may convert what was formerly a serious social and economic problem into a mild and controlled medical syndrome.

Edgar Allen in 1928 clearly demonstrated that after the injection of 1,005 rat units of ovarian hormone into immature female monkeys, over a period of twenty-one days, there was a definite increase in the number of epithelial layers of the vagina to thirty, as compared to from four to eight layers in the control animal. Associated with these changes, the vaginal smears showed an increased number of partly or completely cornified epithelial cells. Allen further showed that involution of the vaginal structures occurred several weeks subsequent to the cessation of the

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