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The Periodicity and Cause of Cancer, Leukæmia and Allied Tumours with Chapters on Their Treatment

JAMA. 1941;117(16):1399. doi:10.1001/jama.1941.02820420091038.
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The author, a well known radiologist, has long been interested in the study of the growth rate of human cancer. The fact that malignant tumors have periods in which they grow rapidly, often though not invariably followed by a latent stage, has been known by clinicians for many years. Pathologists have long noted that the number of mitotic figures, for example, varies enormously from time to time, as determined by multiple biopsies on the same neoplasm. The rhythms of growth noted in grafted animal tumors are dependent more on the nutritional arrangements between the animal host and the tumor and the rise and fall of tissue immunity, owing to the fact that a graft is to a certain extent, even though growing, a foreign material, so that this observation made by Bashford many years ago is not of great interest. When selected stocks homozygous for the tumor inoculated are employed,


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