The large number of patients visiting the renal clinic of the Peter Bent Brigham Hospital during the past seventeen years has afforded an unusual opportunity for the observation of the progressive changes in the ocular fundi in cases of Bright's disease and for their correlation with clinical and laboratory observations. The majority of reports in the literature on the retinal manifestations of chronic glomerular nephritis have consisted of cases in which single or relatively few ophthalmoscopic observations had been made. The patients comprising this series have had frequent examinations over an average period of nearly four years.
It was our original purpose in this investigation to determine the prognostic significance of the severe retinal lesions of chronic glomerular nephritis. We soon found that our group of cases revealed information of even greater significance, several of the features differing from those previously reported by others. These concerned the incidence of the