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R. R. Ferguson, M.D.
JAMA. 1941;117(16):1351-1352. doi:10.1001/jama.1941.72820420001013.
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Among the recently developed clinical applications of heparin therapy is the treatment of thrombosis of the central retinal vein or its tributaries. Although it is likely that work had been done earlier and not reported, prominence was first given to the subject in 1938 when the Lancet published two articles with complete case reports. In the same year a third case was reported by Ploman1 in Acta ophthalmologica.

Holmin and Ploman2 describe the improvement in thrombosis of the central vein of the retina after treatment with heparin. Following this presentation by a few months was a paper by Boström and William-Olsson3 in which is recorded the satisfactory clinical course in a similar case under heparin therapy.

Prompted by the encouraging results thus reported, I elected to employ heparin in the treatment of a patient with thrombosis of the inferior temporal branch of the right central vein of


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