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Exercise Intensity, Dose, and Cardiovascular Disease

Fabian Sanchis-Gomar, MD, PhD1; Carmen Fiuza-Luces, PhD1; Alejandro Lucia, MD, PhD2
[+] Author Affiliations
1Research Institute of Hospital 12 de Octubre (“i + 12”), Madrid, Spain
2European University, Madrid, Spain
JAMA. 2016;315(15):1658-1659. doi:10.1001/jama.2016.0306.
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To the Editor There is growing concern about the potential deleterious effects of high doses of vigorous-intensity exercise on cardiovascular disease (CVD) mortality. Some authors discourage healthy people from engaging in vigorous exercise above a cardiac safety threshold of approximately 60 min/d.1 Recent controversy in the field might detract many people from regular exercise and clinicians from prescribing exercise to their patients.


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April 19, 2016
Thijs M. H. Eijsvogels, PhD; Paul D. Thompson, MD
1Department of Physiology, Radboud University Medical Center, Nijmegen, the Netherlands
2Division of Cardiology, Hartford Hospital, Hartford, Connecticut
JAMA. 2016;315(15):1659. doi:10.1001/jama.2016.0312.
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