We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Covariate Adjustment and Propensity Score—Reply

Jason S. Haukoos, MD, MSc1; Roger J. Lewis, MD, PhD2
[+] Author Affiliations
1Department of Emergency Medicine, Denver Health Medical Center, Denver, Colorado
2Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California
JAMA. 2016;315(14):1522. doi:10.1001/jama.2015.19093.
Text Size: A A A
Published online


In Reply We agree with Dr Garrido that, of the methods listed in our article, matching is likely to be most effective at balancing baseline characteristics between treated and untreated participants, thus eliminating to a greater extent systematic differences between groups.1 Although there appears to be a hierarchy (ie, matching over stratification over covariate adjustment) in terms of the effectiveness of balancing,2 we would like to emphasize the importance of accurate specification of the score prior to its ultimate use. Without proper specification (ie, inclusion of appropriate variables in the propensity score model), even propensity score matching is unlikely to effectively balance study groups. Although the intent of our article was to list common uses of the propensity score (all of which are better than no adjustment for confounding), we recognize certain uses of the propensity score are likely better than others; we did not mean to imply that all approaches were equally useful or effective.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




April 12, 2016
Melissa M. Garrido, PhD
1James J. Peters VA Medical Center, Bronx, New York
JAMA. 2016;315(14):1521-1522. doi:10.1001/jama.2015.19081.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...