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Comment & Response |

Acute Kidney Injury With Buffered Crystalloids vs Saline Among ICU Patients

Alexander H. Flannery, PharmD1; Angel O. Coz-Yataco, MD2
[+] Author Affiliations
1Medical Intensive Care Unit, University of Kentucky HealthCare, Lexington
2Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky HealthCare, Lexington
JAMA. 2016;315(14):1519. doi:10.1001/jama.2016.0145.
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To the Editor A concern regarding the 0.9% Saline vs Plasma-Lyte 148 for ICU Fluid Therapy (SPLIT) trial is the use of normal saline as a ubiquitous diluent for medication delivery in critical care.1 It is not uncommon for patients who are critically ill to receive more than 1 L of normal saline daily from medications alone, not including fluids prescribed for resuscitation or other indications. This amount of normal saline has the potential to diminish the effect size if a difference existed between the normal saline and buffered crystalloid groups.


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April 12, 2016
Paul Young, FCICM; Michael Bailey, PhD; Rinaldo Bellomo, FCICM
1Medical Research Institute of New Zealand, Wellington, New Zealand
2Australian and New Zealand Intensive Care Research Center, Monash University, Melbourne, Victoria, Australia
3Faculty of Medicine, University of Melbourne, Melbourne, Victoria, Australia
JAMA. 2016;315(14):1521. doi:10.1001/jama.2016.0157.
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