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Comment & Response |

Acute Kidney Injury With Buffered Crystalloids vs Saline Among ICU Patients

Kumaresh Venkatesan, FRCA, EDIC, FFICM1
[+] Author Affiliations
1Khoo Teck Puat Hospital, Anaesthesia and Surgical Intensive Care, Singapore
JAMA. 2016;315(14):1519. doi:10.1001/jama.2016.0142.
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To the Editor The SPLIT trial1 tested the hypothesis that using Plasma-Lyte 148 instead of saline for intravenous fluid therapy would decrease the risk of AKI among patients in the ICU. Data have been accumulating based on animal and human studies that saline may be associated with AKI.2 A recent open-label prospective sequential study showed that use of chloride-restricted, balanced salt solutions in patients who are critically ill may be associated with lower incidence of AKI.3


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April 12, 2016
Paul Young, FCICM; Michael Bailey, PhD; Rinaldo Bellomo, FCICM
1Medical Research Institute of New Zealand, Wellington, New Zealand
2Australian and New Zealand Intensive Care Research Center, Monash University, Melbourne, Victoria, Australia
3Faculty of Medicine, University of Melbourne, Melbourne, Victoria, Australia
JAMA. 2016;315(14):1521. doi:10.1001/jama.2016.0157.
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