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JAMA. 1941;117(13):1081-1085. doi:10.1001/jama.1941.02820390023007.
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The local use of sulfanilamide and its related compounds is increasing rapidly, as indicated by numerous reports in the recent literature. Jensen, Johnsrud and Nelson1 implanted sulfanilamide crystals in 39 cases of compound fracture and 2 compound dislocations after careful débridement and hemostasis, followed by primary closure of the skin, with no primary wound infection. In 94 similarly treated cases, but without sulfanilamide, 27 per cent showed infection. Key and Burford2 had a similar experience with compound fractures. They noted also that experimentally produced fractures in rabbits treated locally with sulfanilamide showed as rapid wound and bone healing as those in which the drug was not used. Campbell and Smith3 treated 54 compound fractures, using sulfanilamide both locally and by mouth. Mueller4 used it in the peritoneal cavity in 55 cases of abscess and peritonitis following ruptured appendixes, with no mortality. Many other reports have appeared


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