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SPECIFIC AND NONSPECIFIC REMEDIES IN THE TREATMENT OF ENCEPHALITIS

WALTER FREEMAN, M.D.
JAMA. 1927;89(16):1317-1321. doi:10.1001/jama.1927.02690160025008.
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The treatment of epidemic encephalitis depends greatly on the stage of the disease, whether acute, latent or chronic. During the first stage, the infection and the symptoms are attacked. During the latent period, efforts should be made to increase the resistance of the individual, to eradicate possible foci of infection, and to exterminate whatever organisms have not already been overcome by the defensive forces of the body. In the chronic stage, the attempt is made to stop the progress of the disease and to palliate such distressing symptoms as paralysis agitans and insomnia.

Many antiseptics, such as acriflavine, methenamine and sulphur, have been recommended in combating the infection during the first stage. Among the medicinal substances, however, the salicylates stand foremost. They are used extensively and in large doses, given intravenously if the stomach rebels. Acetylsalicylic acid is perhaps best tolerated, and may be administered in 0.3 Gm. doses every

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