William P. GRAVES, M.D.
JAMA. 1927;89(16):1308-1311. doi:10.1001/jama.1927.02690160016005.
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It is a matter of keen disappointment to clinicians that the new knowledge gained by science of the function and properties of the female sex hormone has not led to a more effective therapy. But as Novak1 well points out, the clinician expects some brilliant specific panacea that will cure every functional disorder to which the complex female pelvic mechanism is heir.

There are numerous reasons why ovarian substance, at least in its present therapeutic form, should be comparatively nonpotent. In the first place the incretory power of the ovary in the normal adult woman is directed chiefly to the pelvic organs for purposes of reproduction, and has little to do with the other functions of her general organism. This is shown by the comparatively small harm that is done by the removal of the secretion. The ovary is not an organ of the same vital significance as the


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